P. foetida has (sub)globose fruits and a very wide distribution in South-East Asia while P. cruddasiana Prain has laterally compressed-ovoid fruits, which are distinctly winged, and which occurs from northern India, Bangladesh, Nepal, Bhutan to south-western China and Thailand. An excellent, if rather terse, guide to the traditional medicinal uses of the plants of the region The root is mixed with gin and used as a treatment for back pain[ 348 In: Puff (ed.) Paederia foetida Linn. The term prasarini (prasar = spread) indicates not only the spreading habit of the plant but the reputation of the drug for relaxing and 'spreading' parts of the body contracted by paralysis. & Bhavsar, G.C., 1994. The word meaning of Gandha Prasarini in Sanskrit is – it spreads bad smell! LD50was found to be greater than 2 g/kg in rats and mice upon oral as well as intraperitoneal treatments. "P. foetida is mainly propagated by seed." Fruit a drupe, (sub)globose, 4-6 mm in diameter, walls thin, dry, brittle, crowned by the persistent sepals, shiny pale brown to yellowish- or reddish-brown; pyrenes 2, semi-orbicular or semi-ellipsoidal, plano-convex or compressed, slightly smaller than fruit, without conspicuous wings, black, often conspicuously covered with raphides. Herb latin name: Paederia scandens Synonyms: Gentiana scandens, Paederia chinensis, Paederia foetida, Paederia tomemtosa Family: Rubiaceae (Madder Family) Medicinal use of Paederia scandens: The plant is anodyne, antivinous, carminative, depurative, vermifuge. Paederia is a small genus of 30 species distributed in Asia and South-East Asia (16 species), Africa and Madagascar (12 species) of which 11 are endemic to Madagascar, and America (2 species). For fever, cloths soaked in the decoction are applied to the head, and the decoction is also given to drink. Over the past decade, herbal and ayurvedic drugs have become a subject of world importance, with both medicinal and economical implications. It is a host for the root-knot nematode Meloidogyne sp. 6.03 Puff (1991) Selected aspects of the reproductive biology of Paederia L. (Rubiaceae - Paederieae). The leaves are antirheumatic. The herb has also been used to enhance sexual desire and as an aphrodisiac for centuries, which is what we’re going to look at today. There is very limited evidence to … Hepatoprotective activity: The methanol extract showed moderate hepatoprotective activity. Especially the disease-modifying component merits attention. Antispasmodic activity: A 50% ethanolic extract of Paederia foetida exhibited antispasmodic activity on the isolated guinea pig ileum. A decoction of the whole plant is used in the treatment of abdominal pain, abscesses, arthritis, overeating etc[147, 218]. Singh, S., Bani, S., Khajuria, A., Sharma, M.L., Singh, G.B., Suri, K.A. P. foetida is used on a local scale only. Medicinal plants of Vietnam, Cambodia and Laos. It reduced the degradation changes in the articular cartilage induced by ananase and in vitro studies using ananase-treated chick embryonic bones showed that the plant (at a dose of 10 mg/ml of the medium) enhanced the growth of the chick bones cultivated in this medium. Paederia foetida is a potential medicinal plant [2, 3] P. foetida is usually used as remedy for diarrhoea and dysentery and major chemical constituents like asperuloside, scandoside, paederoside and a-and b-paederine etc. The fruits are used to prevent toothache. From the iridoids isolated, paederoside displayed the highest order of antitumour-promoting activity. Maha Narayan Oil – widely used pain relieving massage oil Marma Gulika– used in disorders of heart, kidney etc. 11 volumes. Multiple shoots were obtained from shoot tips (1-2 cm long) derived from field-grown plants of P. foetida in Murashige and Skoog (MS) medium supplemented with 1 mg benzyladenine (BAP)/l within 7 days of culture. Merr. Linalool is the major component of the oil obtained from the stem, leaf and flower, together with a-terpineol and geranio1.2 The leaf and stem also contain hentriacontane, hentriacontanol and ceryl alcohol, 2,3-dihydrobenzofuran, benzofuran and the sulphur-containing compounds dimethyl sulphide and dimethyl trisulphide. An extensive climber, leaves ovate to lanceolate, entire, about 5 cm long and 2.5 cm broad, membranous with long petioles. Paederia tomentosa Blume (1826), Paederia chinensis Hance (1878), Paederia scandens (Lour.) In India, the juice of the root is also prescribed in piles, inflammation of the spleen, and pain in the chest and liver. P foetida is also reported to have ethno medicinal uses … Activity was also observed in chronic models of adjuvant and formaldehyde arthritis in rats. Bruised aerial parts of the plant have the fetid odour of indole (methyl-mercaptan). Backhuys Publishers, Leiden. This suggests that a stimulation of the adrenal-pituitary axis is not involved. The roots are used as an emetic and the juice extracted from the roots is given in cases of inflammation of the spleen and for pains in the chest and liver. It decreased liver aspartate transaminase activity without affecting serum aspartate transaminase activity. Bees and butterflies have been observed to visit the flowers. and moderately effective against Bunostomum and Monezia spp., when given at 2-day intervals in young calves. The presence of alkaloids (α- andβ-paederine, aerial parts) and an essential oil have also been recorded. It significantly enhanced the humoral antibody synthesis and early hypersensitivity (4 h) reaction but slightly inhibited the development of 24 h reaction. Damage to the tissue releases an enzyme which splits off this sulphur-containing group from paederoside, and is therefore responsible for the unpleasant odour. The stem yields a strong and silky fibre, but it is not commercially exploited. Mekong Printing, Santa Ana, California, United States. P. foetida is harvested from the wild whenever needed. Vietnam: dây mơ lông, dây mơ tròn, mơ tam thể. The antioxidant activity of fresh and dried plant extracts of Paederia foetida and Syzygium aqueum were studied using β-carotene bleaching and the 2,2’-azinobis(3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS) radical cation assay. Paederia foetida and P. scandens are two important and well explored Paederia species (Rubiaceae). The fruits are compressed, ellipsoid, red or black in colour. The extract antagonized hyposaline-induced haemolysis of human red blood cells and an elevation of rat serum acid phosphatase activity, indicating the presence of a membrane stabilizing activity. Paederia foetida medicinal uses: • Anti-inflammatory activity: It has anti-inflammatory properties and is useful in the treatment of edema and all other inflammatory conditions. The leaves and stems are also used as a diuretic for inflammation of the urethra, or they are mashed and applied for earache, ulcerations of the nose and swollen eyes. Despite its weediness, P. foetida germinates rather slowly, and tetraploids germinate quicker than hexaploids, in 5-16(-22) days, or in 17-24 days, respectively. asperuloside, scandoside and paederoside were isolated from the aerial parts of P. foetida . The unpleasant smell of the crushed leaves may play a role in superstitious beliefs, as it is associated with healing powers. Ministry of Agriculture and Co-operatives, Kuala Lumpur, Malaysia. The LDso of a 50% ethanolic extract of leaves was 1200 mg/kg in mice. Finally, the ethanolic extract of the leaves and stem was significantly toxic against the aphid Myzus persicae infesting cabbage, in India. The leaves are antirheumatic. 147. For intestinal problems, fresh leaves are pounded, water added, and the … Uses. Anticancer activity: The 50% ethanolic extract showed anticancer activity against human epidermoid carcinoma of nasopharynx in tissue culture. It has been introduced into North America (North Carolina, Texas, Louisiana), Hawaii, Christmas Islands, Mauritius and Reunion as an ornamental and escaped. The genus Paederia L.: a multidisciplinary study. The leaves are anodyne, antirheumatic, antivinous, astringent, carminative, depurative, diuretic, restorative and vermifuge [147, 218, 310 ]. Singh, S., Ray, B.K., Mathew, S., Buragohain, P., Gogoi, J., Gogoi, S., Sharma, B.K. The intense odour is due to methyl mercaptan. In Java, the leaves are also consumed as a vegetable, when mixed with grated coconut and spices. Vol. The whole plant shows tonic, astringent and antiphlogistic actions and has been used in tenesmus.Whole plant, leaves, roots. (1934). The leaves of P. foetida are widely used in Asia and South-East Asia for the treatment of intestinal complaints such as colic, cramps, flatulence, dysentery and also for rheumatism and gout. The northeastern region of India constitutes one of the biodiversity hotspots of the world. Medicinal and poisonous plants. It may help to eliminate poisons collected in the system. It also grows in montane vegetation up to 3000 m altitude, on steep, forested slopes, or on sandy or rocky sea coasts. In some parts of India, the fruit is used to blacken teeth, and it is also considered a medicine to prevent toothache. Micropropagation of a few important medicinal plants. 1 (A-H) pp. Opera Botanica Belgica 3: 167 -178. Paederia foetida is an indigenous plant belongsto family Rubiaceae. Sometimes, shoots produce adventitious roots when they come in contact with the soil, and can thus be propagated as well. The leaf contains a mixture of fatty acids including non-ionic, capric, lauric, myristic, arachidic and palmitic acids. This fraction produced a significant inhibition of granulation tissue formation in cotton-pellet implanted rats. The genus Paederia L. (Rubiaceae-Paederieae): a multidisciplinary study. Kapadia, G.J., Sharma, S.C., Tokuda, H., Nishino, H. & Ueda, S., 1996. De, S., Ravishankar, B. The extract showed effectiveness in reversing 6 out of 12 common biochemical (enzymatic) parameters assessed. 1-1240, Vol. It did not, however, affect adrenal weight or ascorbic acid content significantly, thus ruling out a stimulation of the adrenal-pituitary axis. Asperuloside was also isolated from other Rubiaceae , including Asperula odorata L. and several Coprosma species. Annals of Biology Ludhiana 15(1): 1-7. It has been found in Chinese herbalist shops in Peninsular Malaysia. Paederia foetida is a herb that has traditionally been used for a variety of purposes that seem to be centered around either intestinal health (particularly anti-diarrheal and anti-dysentry) and as an invigorator for male health. It is a unique feature of this herb. Purple or violet flowers are found in scorpioid cymes. In India, the leaves are often boiled in soup to lessen their smell. Ayurvedic medicine with Paederia foetida- Prasarini Thailam – used in arthritis, sciatica etc. The results suggest that the plant extract has analgesic and antidiarrhoeal activities, supporting its uses in traditional medicine. Individual flowers are short-lived, open early in the morning and fall off after 2 days; entire inflorescences, however, bear flowers for a long period of time. It is extensively used in … (Rubiaceae), Journal of Ethnopharmacology, 105, 125–130. Home | About Us | Herbs A to Z | Terms & Conditions | Contact Us, Copyright © Krishna Herbal Company 2018. The main use The main use of the plant is for arthritis and:rheumatic disorders. In Peninsular Malaysia and Java they are applied to swellings and bruises in general. The plant is having a broad spectrum of use as in treatment of hepatic disorders, rheumatoid arthritis, There are no known breeding programmes of P. foetida . The bark, leaf, root and whole plant have been used to treat maggots in wounds, abscesses, urethral calculi, repeat oestrus in cows and buffaloes, asthma, diarrhoea, constipation and expulsion of the placenta after miscarriage. P. foetida, which grows mainly in China, Bangladesh, India and Mauritius, has been used in folk medicine for the treatment of inflammation, piles, and diarrhea, while P. scandens is used to treat aches, jaundice, dysentery and dyspepsia as a folk medicine in the southern region of China, Vietnam, India and Japan. The results also demonstrate that the plant extract possesses cytotoxic activities. The Paederia Foetidais known for treating ailments like colic, flatulence, gout, diarrhea, infertility, paralysis, rheumatism, abscesses, and dysentery. P. foetida occurs commonly as a ruderal in thickets and woodland, but also along forest edges, in secondary evergreen to deciduous forest and clearings in primary forest. The percentage of antioxidant activity for all extract samples using both assays was between 58 and 80%. Inhibitory effect of iridoids on Epstein-Barr virus activation by a short-term in vitro assay for anti-tumor promoters. Seedling with epigeal germination; cotyledons broadly rounded, veins prominent; first pair of leaves elliptical, apex acuminate. Parts of P. foetida are mainly used fresh, but can be dried for later use. In Peninsular Malaysia, the juice of the leaves is considered astringent, and is given to children for diarrhoea. In the carrageenan pleurisy test in rats, it reduced the pleural exudate volume and inhibited the migration of leucocytes into the inflammatory site. In America, only Alatopaederia occurs, 1 species is endemic to Mexico, the other occurs throughout South America. Triterpenoids and saponins Ursolic acid, epifriedelinol, friedelin. In Java, the leaves are applied as a poultice for a swollen belly, distension, herpes or ringworm. The most abundant sulphur-containing compound was dimethyl disulphide. Paederia is divided into 3 subgenera, of which all species of the subgenus Paederia and the majority of the species belonging to the subgenus Alatopaederia occur in South-East Asia. Investigation of the anti-inflammatory effects of Paederia foetida. It failed to exhibit any analgesic or antipyretic action and showed no ulcerogenic potential. Inflorescence a terminal or axillary cymose panicle, extremely variable, from widely branched paniculate, over 1 m long to rather reduced, 10 cm long; bracts foliaceous or small and linear, with few to numerous flowers, often in lax scorpioid cymes; peduncle 2-30 mm long. The leaf and stem contain sitosterol, stigmasterol and campesterol. The wealth of India: a dictionary of Indian raw materials & industrial products. Trichostrongylus and Haemonchus spp. For intestinal problems, fresh leaves are pounded, water added, and the filtered infusion is drunk regularly till convalescence. Fitoterapia 65(4): 357-362. Antiarthritic activity: Paederia foetida extract was tested for its effect on osteoarthritis-like lesions induced in the knee joints of rabbits by ananase (the proteolytic enzyme from pineapple). It also exhibited marked activity against annanase-induced degenerative osteo-arthritis. P. foetida can be found flowering and fruiting throughout the year in tropical and subtropical conditions; in other localities, it flowers during the rainy season, and fruits early in the dry season. Extracts of P. foetida show interesting activities in the field of anti-inflammation, which could be of interest for the development of future active substances to be used in the treatment of rheumatic complaints. relieve distension due to flatulence and in herpes infections. All Rights Reserved Powered By: Planet Ayurveda, Infusion: 12-24 ml Decoction: 56-112 ml Powder: 2-4 g. Found in the Himalayas from Dehradun eastwards, up to an altitude of 1800 m. It is also found in Bihar, Orissa, Bengal and Assam. This is because the oil responsible for the smell, and found primarily within the leaves, contains sulphur compounds, including largely dimethyl disulphide. Among the less-studied plants, Paederia foetida has been used by various ethnic tribes as food and medicine. The hepatoprotective potential of a leaf methanol extract has been assessed against CCl4-induced liver damage in the rat model. Paederia foetida L. is an important medicinal herb harboring lots of essential drug producing metabolites and the plant has been going to be endangered due to lack of proper strategies for conservation. Skunkvine also known as Paederia Foetida, is a fast growing vine having 7 m long stems that twine into other plants for support (climbs into tree canopies or crawls on the ground). P. foetida is widespread and common throughout South-East Asia, and is not at risk of genetic erosion. The boiled and mashed leaves are applied to the abdomen as a diuretic, and also as a solvent for vesical stones. P. foetida is mainly propagated by seed. Cancer Letters 102(1-2): 223-226. Opera Botanica Belgica 3: 1-376. 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