EGBE is manufactured by adding n-butyl alcohol and ethylene oxide. 2-Butoxyethanol is an organic compound with the chemical formula BuOC 2 H 4 OH (Bu = CH 3 CH 2 CH 2 CH 2).This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol.As a relatively nonvolatile, inexpensive solvent, it is used in many domestic and industrial products because of its properties as a surfactant. Where is it found and how is it used? Int Arch Occup Environ Health. 1987 Nov;91(2):222-34. Miller RR, Hermann EA, Young JT, Landry TD, Calhoun LL. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. (USCG, 1999) Nausea and … Int J Toxicol. Opinion on Ethylene glycol monobutyl ether _____ 7 3.1.9. This substance ranges from B to C depending on concentration/usage. During 2003, the production of EGBE in the European Union was approximately 161,000 tonnes. ICSC Routes of Exposure and Symptoms. Experimental studies on toxicity of ethylene glycol alkyl ethers in Japan. In evaluating the hazard that this chemical … 1984 Aug;57:233-9. doi: 10.1289/ehp.8457233. Abbreviations for 2-butoxyethanol include EGBE and BE [1]. This assessment summarizes available information on Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate … Effects of short-term exposure The substance is irritating to the eyes, skin and respiratory tract. 1992;18(4):250-1. doi: 10.1007/BF01709843. Effects of short-term exposure The substance is irritating to the eyes, skin and respiratory tract. Environ Health Perspect. 2-Butoxyethanol autoprotection is due to resiliance of newly formed erythrocytes to hemolysis. Please contact NTP, IARC, or EPA’s IRIS Hotline with questions on cancer and cancer classification. Bauer P, Weber M, Mur JM, Protois JC, Bollaert PE, Condi A, Larcan A, Lambert H. Intensive Care Med. Comparative acute and subchronic toxicity of ethylene glycol monopropyl ether and ethylene glycol monopropyl ether acetate. (ethylene glycol monobutyl ether) [CAS No. 2-Butoxyethanol (ethylene glycol monobutyl ether): Target Organs and Levels of Evidence for TR-484 Toxicology and Carcinogenesis Studies of 2-Butoxyethanol (CASRN 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) Summary about a hazardous substance taken from Chapter One of its respective ATSDR Toxicological Profile. 1995;69(8):526-32. doi: 10.1007/s002040050207. NIOSH Pocket Guide to ... in this product - not the product itself - compared to other product formulations. 4 Fukushima Medical University. Environ Health Perspect. It is also used in some ink and spot remover compounds. : 111-76-2 Formula : C6H14O2 Synonyms : 2-butoxyethanol / BGE / butyl cellosolve / butyl OXITOL / butylglycol / butylglycol ether / EGBE / ethanol, 2-butoxy- / ethyleenglycolmonobutylether / ethylene glycol monobutyl ether / glycolmonobutylether / monobutyl ether … 2-Butoxyethanol (2-BE), also known as ethylene glycol monobutyl ether, is a clear liquid with an ether-like odour. NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC) ... compared to other product formulations. Ethylene Glycol Monobutyl Ether 111-76-2 <25 * *The exact percentage (concentration) of composition has been withheld as a trade secret. In view of recent findings with other chemically related glycol ethers, particular attention has been given to possible adverse effects on blood and testicular tissue. ETHYLENE GLYCOL N-BUTYL ETHER may react with bases, aluminum and oxidizing materials. Animal studies have reported reproductive and developmental risks from inhalation … 4. Ethylene glycol monomethyl ether and propylene glycol monomethyl ether: metabolism, disposition, and subchronic inhalation toxicity studies. It attacks some forms of plastics, rubber and coatings. Office of Pesticide Programs Pesticide Chemical Search. METHODS 53 Impregnation workers from two factories that make copper clad laminate with EGME as a solvent were recruited as the exposed group. Workers may be harmed from exposure to 2-butoxyethanol. Gaschromatographic determination of butoxyacetic acid after hydrolysis of conjugated metabolites in urine from workers exposed to 2-butoxyethanol. Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate and propyleneimine, and classifications on carcinogenicity, occupational sensitizer and reproductive toxicant. Print Share on: Evidence. 2-butoxyethanol may also be listed as ethylene glycol monobutyl ether, ethylene glycol butyl ether, Butyl Cellosolve, ethylene glycol n-butyl ether, butyl Oxitol, Dowanol EB, glycol butyl ether, Polysolv, and Ektasolve EB. It is liable to form peroxides on exposure to air and light. Skin Contact Rinse with clear water SUBJECT: Reassessment of Tolerance Exemptions for Ethylene Glycol, Diethylene Glycol, Diethylene Glycol Monomethyl Ether, Diethylene Glycol Monoethyl Ether, and Diethylene Glycol Monobutyl Ether FROM: Kit Farwell, D.V.M. ETHYLENE OXIDE Causes reproductive effects . Archives of Toxicology, 82(2), 125-136. ICSC Long-Term Exposure. Cohen, R. (1984) Reversible subacute ethylene glycol monomethyl ether toxicity associated with microfilm production, a … Read More. Precautions. GENERIC NAME(S): Carbitol (Bulk) ... You may report side effects to Health Canada at 1-866-234-2345. 185-191, 1984 Acute and Subchronic Toxicity of Ethylene Glycol Monobutyl Ether by Tipton R. Tyler* The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. The main systemic adverse effects of 2-butoxyethanol are on the haematopoietic system (haemolytic effects), followed by possible teratogenic and testicular effects. In the first study, a group of two men and six rats were exposed simultaneously for 4 hours to an EGBE concentration of 113 ppm in a 1,250 cubic ft room. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. People who swallowed large amounts of cleaning agents containing 2-butoxyethanol have shown breathing problems, low blood … Summary: 2-Butoxyethanol is a clear colorless liquid that smells like ether. 2-Butoxyethanol is an organic compound with the chemical formula BuOC 2 H 4 OH (Bu = CH 3 CH 2 CH 2 CH 2).This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol… (1993) Technical report on toxicity studies of ethylene glycol ethers 2-methoxyethanol, 2-ethoxyethanol, 2-butoxyethanol administered in drinking water to F344/N rats and B6C3F1 mice. It is concluded that the available information continues to support the current ACGIH TWA8-TLV of 25 ppm with a STEL of 75 ppm. Health Hazard Assessments for Noncarcinogenic Effects . Toxicol Appl Pharmacol. Toxicol Lett. Pubmed Abstract  |  The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. Symptoms/effects after skin contact : Harmful in contact with skin. Symptoms may include tiredness, … Ethylene Glycol Monobutyl Ether; Community Right-To-Know Toxic Chemical Release Reporting, 60818-60825 [2015-25674] 0.03ppm; P=0.017). Diethylene glycol (DEG) is an organic compound with the formula (HOCH 2 CH 2) 2 O. 1974 Feb;27(2):342-54 DIETHYLEN Glycol M-ETHYL ETHER Liquid. 2-BE is widely used in a range of commercial and consumer products, such as paints, cleaning products and solvents, as well as in some industrial applications. -, Sangyo Igaku. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. Ethylene Glycol Monobutyl Ether 111-76-2 <25 * *The exact percentage (concentration) of composition has been withheld as a trade secret. This database provides human health benchmarks for pesticides that may be present in drinking water. It is also used in liquid soaps, cosmetics, industrial and household cleaners, and dry-cleaning compounds. USA.gov. DIPROPYLENE GLYCOL BUTYL ETHER . Vapors irritate eyes and nose. Aspects of biological monitoring of exposure to glycol ethers. This can cause anemia. Where is it found and how is it used? It is miscible in water, alcohol, ether, acetone, and ethylene glycol… In view of recent findings with other chemically related glycol ethers, particular attention has been given to possible adverse effects on blood and testicular tissue. J Occup Health. 2-BE itself is not commercially produced in Canada. 2-Butoxyethanol was classified in REACH regulation aims to improve the protection of human health and the environment from the risks that can be ... new labelling, classification or hazard statement, neither reflect other factors that affect the susceptibility of the effects ... 2-butoxyethanol ethylene glycol monobutyl ether butyl cellosolve . Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, ... 2 Japan Industrial Safety and Health Association. 4.3. 3 Independent Consultant. 1988 Oct;43(1-3):5-21. doi: 10.1016/0378-4274(88)90017-3. Chemical Name. ETHYLENE GLYCOL ETHERS PANEL TO REMOVE ETHYLENE GLYCOL MONOBUTYL ETHER FROM THE TOXICS RELEASE INVENTORY UNDER SECTION 313 OF THE EMERGENCY PLANNING AND COMMUNITY RIGHT-TO-KNOW ACT OF 1986 Jonathon Busch Director, Ethylene Glycol … 3 Independent Consultant. The substance can be absorbed into the body by inhalation, through the skin and by ingestion. The MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse, non-cancer health effects over a specified duration of exposure. 1. It can harm the eyes, skin, kidneys, and blood. It is an ether-ester derivative. tration. Ingestion or skin contact causes headache, nausea, vomiting, dizziness. Would you like email updates of new search results? A 2010 EPA re-evaluation found that ethylene glycol monobutyl ether is not likely to be carcinogenic to humans for exposures at or below reference concentrations or doses and in the absence of critical noncancer effects… Starek, A., Szymczak, W. and Zapór, L. (2008) Hematological effects of four ethylene glycol monoalkyl ethers in short-term repeated exposure in rats. Flammable and/or toxic … Initial adverse health effects caused by ethylene glycol intoxication include central nervous system depression, intoxication, euphoria, stupor, and respiratory depression. Acute toxicity: Oral: Harmful if swallowed. J Occup Health. 1994;66(4):249-54. doi: 10.1007/BF00454363. 111-76-2) In Support of Summary Information on the Integrated Risk Information System (IRIS). Ethylene Glycol Ethers Group - information sheet - Canada.ca Find Lowest Prices. Exposure to 60 ppm aerosolized ethylene glycol caused very noticeable irritation. Some chromatograms showed that subjects were co-exposed to m-xylene, ethylene glycol monomethyl ether, and ethylene glycol monoethyl ether acetate. The ether being relatively unreactive. Please enable it to take advantage of the complete set of features! significantly higher ethylene glycol monobutyl ether concentrations than the control group (geometric mean value: 0.14vs. Teratologic evaluation of ethylene glycol monobutyl ether in Fischer 344 rats and New Zealand white rabbits following inhalation exposure. 1984 Aug;57:165-75. doi: 10.1289/ehp.8457165. NIOSH Criteria for a Recommended Standard. Precautions. Toxicological Review of Ethylene Glycol Monobutyl Ether (EGBE) (CAS No. According to " DISCLAIMER: The ILO does not take responsibility for content presented on this web portal that is presented in any language other than English, which is the language used for the initial production and peer-review of original content. In both the ethylene and diethylene glycol series, the relative rate of absorption declined from methyl to ethyl to butyl ether derivatives. Likely routes of exposure : Inhalation; Skin and eye contact .  |  Occupational Exposure to Ethylene Glycol Monobutyl Ether and Ethylene Glycol Monobutyl Ether Acetate. -. 2-Butoxyethanol is a clear colorless liquid that smells like ether. A U.S. … Throat and upper respiratory irritation were the most common complaints following prolonged experimental exposures in humans (4 weeks at concentrations of 1-25 ppm). The substance may cause effects on the central nervous system, blood, kidneys and liver. Diethylene glycol (DEG) is an organic compound with the formula (HOCH 2 CH 2) 2 O. 2-Methoxyethanol (McGregor et al., 1983), ethylene glycol monobutyl ether (Tyler, 1982), dlethylene glycol monobutyl ether (Thompson et al., 1984), dlethylene glycol dimethyl ether (McGregor et al., 1983), propylene glycol methyl ether {Mendrala, 1983c), and dlpropylene glycol methyl ether (Mendrala, 1983b) were negative 1n the cell culture test for unscheduled DNA synthesis. Clipboard, Search History, and several other advanced features are temporarily unavailable. Studies on EGM using hamsters or guinea pigs revealed the occurrence of testicular atrophy similar to that observed in mice. 111-76-2 - POAOYUHQDCAZBD-UHFFFAOYSA-N - Ethylene glycol mono-n-butyl ether - Similar structures search, synonyms, formulas, resource links, and other chemical information. Final report on the safety assessment of Triethylene Glycol and PEG-4. DEG is a widely used solvent. ethylene glycol was prepared by the Institute of Terrestrial Ecology, United Kingdom, based on the report Environmental hazard assessment: Ethylene glycol (Nielsen et al., 1993). NIH Studies on ethylene glycol alkyl ethers and related compounds … 2-Butoxyethanol (2-BE), also known as ethylene glycol monobutyl ether, is a clear liquid with an ether-like odour. Information on toxicological effects . 1970 Jan;27(1):1-18 Effects observed in humans included nasal and … 2006;25 Suppl 2:121-38. doi: 10.1080/10915810600964642. ETHYLENE OXIDE Causes reproductive effects . ICSC Short-Term Exposure. Chronic exposure in humans is associated with neurological and blood effects, such as nausea, tremor, and anemia. Fact sheet that answers the most frequently asked questions about a contaminant and its health effects. 1979 Jan;21(1):29-35 Reference Dose (RfD) for Chronic Oral Exposure . Health Effects Division (7509C) Pauline Wagner, Chief Inert Ingredient Assessment Branch (IIAB) Registration Division (7505C) BACKGROUND Attached is the science assessment for one exemption from the requirement of a tolerance for ethylene glycol monobutyl ether (EGBE). by Alicia Minns, MD. The ratings reflect potential health … In humans, 100 ppm (69 mg/kg bw/day) resulted in ocular and respiratory Irritation, altered taste and nausea (Carpenter et al., 1956). Epub 2017 Jun 26. For more information about this message, please visit this page: Agency for Toxic Substances & Disease Registry, 2-Butoxyethanol and 2-Butoxyethanol Acetate, Health Effects of Exposure to Substances and Carcinogens, Community Environmental Health Education Presentations, Case Studies in Environmental Medicine (CSEM), Toxicology Curriculum for Communities Trainer's Manual, Compendium of Papers on MRLs and Health Effects, Agency for Toxic Substances and Disease Registry. Most important symptoms and effects, both acute and delayed Symptoms/effects after inhalation : Harmful if inhaled. It is used as a solvent for lacquers, varnishes, enamels, and epoxy resins. Substance name : Glycol Ether EB CAS-No. Fast, free, expert help 24×7×365 1‑800‑222‑1222. For this reason, some items on this page will be unavailable. In this document, NIOSH recommends occupational exposure limits for ethylene glycol monobutyl ether (EGBE) and its acetate, ethylene glycol monobutyl ether acetate (EGBEA). In evaluating the hazard that this chemical may pose to man, consideration has been given to likely routes of exposure and its irritant properties. Cincinnati, OH, US Department of Health and Human Services, National Institute for Occupational Safety and Health, Division of Standards Development and Technology Transfer, 1990. Environmental Health Perspectives Vol. The information in this MRL serves as a screening tool to help public health professionals decide where to look more closely to evaluate possible risk of adverse health effects from human exposure. Ethylene Glycol 107-21-1 Hazard Summary Ethylene glycol has many uses, including as antifreeze in cooling and heating systems, in hydraulic brake fluids, and as a solvent. Diethylene Glycol Poisoning GENERIC NAME(S): Carbitol (Bulk) ... You may report side effects to Health Canada at 1-866-234-2345. EPA/635/R-08/006F. Epub 2017 Jun 26. CAS-Number. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. COVID-19 is an emerging, rapidly evolving situation. Function and uses EGBE belongs to the group of glycol ethers, which are mainly used as solvents. … It is used as a solvent in spray lacquers, enamels, varnishes, and latex paints and as an ingredient in paint thinners and strippers, varnish removers, and herbicides. Inhalation: Toxic ifinhaled. Ethylene Glycol Monoethyl Ether (110-80-5) LD50 oral rat 1746 mg/kg LD50 dermal rabbit … Ethylene … -, Nature. 2017 Jul 27;59(4):364-366. doi: 10.1539/joh.17-0148-OP. Effect of age on the toxicity and metabolism of ethylene glycol monobutyl ether (2-butoxyethanol) in rats. Br J Ind Med. No harmful effects were seen on their lungs or hearts. 1977 May 26;267(5609):335 Read More. Information available on … 2-Butoxyethanol (bu-tox-zi-eth-an-ol) has many names, including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellosolve, butyl glycol, ... if they do, what the type and severity of these health effects … This chemical inventory is OSHA's premier one-stop shop for occupational chemical information. Ethylene glycol monobutyl ether has also been tested for teratogenldty … O-butyl ethylene glycol butyl glycol EGBE ethylene glycol n-butyl ether glycol butyl ether monobutyl glycol ether 3-oxa-1-hepatanol Chemical name (CAS) 2-butoxyethanol CAS number 111-76-2 Since the MAK documentation from 1983 and 1986 (“2-Butoxyethanol”, Volume 6, EPA has denied a petition to remove Ethylene Glycol Monobutyl Ether ... toxicity data for EGBE and concluded that it can reasonably be anticipated to cause serious or irreversible chronic health effects in humans, specifically, liver toxicity and concerns for hematological effects. Environ Health Perspect. 2-Butoxyethanol acetate is a colorless liquid with a fruity odor. -, Toxicol Appl Pharmacol. Acute (short-term) exposure of humans to ethylene glycol by ingesting large quantities causes three stages of health effects… It is also known as ethylene glycol monobutyl ether acetate, butoxyethyl acetate, butyl glycol acetate, ethylene glycol butyl ether acetate, and acetic acid 2-butoxyethyl ester. 1984 Aug;57:75-84. doi: 10.1289/ehp.845775. I. It has many names including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellusolve, butyl glycol, and butyl Oxitol. some . 1. FIRST AID MEASURES First aid measures Eye contact Rinse … 111-76-2], considering butoxyacetic acid in urine to characterise the internal exposure. It has many names including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellusolve, butyl glycol… Arch Toxicol. The acute and subehronic toxicity of EGEE, EGPE and EGBE was reviewed by C. C. Conaway (Texaco, 2-Butoxyethanol (bu-tox-zi-eth-an-ol) has many names, including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellosolve, butyl glycol, butyl Oxitol, glycol butyl ether… 2-BE …  |  Nagano K, Nakayama E, Oobayashi H, Nishizawa T, Okuda H, Yamazaki K. Environ Health Perspect. Histopathological effects consisted of excessive extramedullary splenic hematopoiesis, renal tubular degeneration, hemosiderin deposition in the spleen and kidney and accumulation in Kupffer cells, and … some . ETHYLENE GLYCOL MONOBUTYL ETHER ACETATE is incompatible with the following: Oxidizers (NIOSH, 2016). Reregistration Branch 1 Health Effects … Stability No data submitted 3.2. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate and propyleneimine, and classifications on carcinogenicity, occupational sensitizer and reproductive toxicant ... 2 Japan Industrial Safety and Health Association. Substance Name — Ethylene glycol monobutyl ether (EGBE) CASRN — 111-76-2 Last Revised — 3/31/2010 . U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health… Respiratory Effects: Inhaled ethylene glycol can irritate the respiratory tract. Find Lowest Prices. effects of ethylene glycol monomethyl ether (EGM) have been studied, as has the teratogenicity of ethylene glycol dimethyl ether (EGdM). NLM FIRST AID MEASURES First aid measures Eye contact Rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids. This site needs JavaScript to work properly. ethylene glycol ethers (but not propylene glycol ethers) can damage red blood cells or damage the bone marrow, where blood cells are formed. Google Scholar It compiles information from several government agencies and organizations. Consult a physician. 1983 May;68(3):405-14 Another group of 121 lamination workers with indirect exposure to EGME was recruited as the control group. The level of exposure depends upon the dose, duration, and work being done. The publication also examines the occupational health risks of exposure to these chemicals and presents criteria for eliminating or minimizing these risks during the manufacture and use of EGBE and EGBEA. OBJECTIVES To investigate the effects of ethylene glycol monomethyl ether (EGME) on haematology and reproduction in exposed workers. I.A. The RfD is an estimate (with uncertainty … 11.1. Diethylene glycol ethers were absorbed more slowly than the corresponding ethylene glycol ethers. 2017 Jul 27;59(4):364-366. doi: 10.1539/joh.17-0148-OP. 2-BE itself is not commercially produced in Canada. Tyl RW, Millicovsky G, Dodd DE, Pritts IM, France KA, Fisher LC. 57, pp. 2-Butoxyethanol … 4. NIOSH IDLH: The National Institute for Occupational Safety and Health Immediately Dangerous to Life or Health Ethylene Glycol Monobutyl Ether (Laboratory) Revision Date 15-Dec-2015 Engineering … ETHYLENE GLYCOL MONOBUTYL ETHER ACETATE For Synthesis Safety Data Sheet www.lobachemie.com 03/06/2016 3/8 4.2. -, Toxicol Appl Pharmacol. DIETHYLEN Glycol M-ETHYL ETHER Liquid. Transient non-cardiogenic pulmonary edema following massive ingestion of ethylene glycol butyl ether. 1984 Aug;57:47-68. doi: 10.1289/ehp.845747. US NIOSH Target Organs & Routes of Entry DIPROPYLENE GLYCOL BUTYL ETHER can be found in 39 products. 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